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KMID : 0352519820190030731
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Korea Univercity Medical Journal
1982 Volume.19 No. 3 p.731 ~ p.740
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A Study on the Immunohistochemical Detection of Carcinoembryonic Antigen (CEA) in Lung Cancer Tissues
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蘇文永/So, Moon-Young
金仁仙/白承龍/Kim, In-Sun/Paik, Seung-Yong
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Abstract
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The advent of immunohistochemical technique has allowed the more conventional visu-
alization by light microscopy of antigenic cellular constituents. Carcinoembryonic antigen (CEA), which had been thought to be present in colorectal carcinomas only, was later
demonstrated in a variety of malignancies as well as nonmalignant diseases.
Using formalin-fixed, paraffin-embedded tissues and immunoperoxidase, the author has
attempted to demonstrate CEA in 40 lung cancers and 10 nonmalignant diseases. The results obtained are as follows:
1. Seventeen squamous cell carcinomas among 19, three adenocarcinomas among 4 and only 3 of the 12 small cell carcinomas of the lung were positive for CEA. Two mucoepidermoid tumors and one carcinosarcoma were all positive, whereas one carcinoid tumor and one large cell carcinoma were negative for CEA.
2. In the well differentiated squamous cell carcinoma of the lung it was almost exclusively the more keratinized squamous tumor cells that displayed CEA, whereas in the poorly differentiated squamous cell carcinoma and adenocarcinema the total cell surfaces demonstrated CEA. In mucoepidermoid tumors, the total cell surfaces and the luminal borders of the glandular structures were positive for CEA. The stainability of CEA was weak and focal in small cell carcinoma.
The stronger staining of CEA was found in the carcinomatous portion of carcinosarcoma.
3. Except two middle lobe syndromes and one tuberculosis of the lung, 2 bronchiectasis, 2 pneumonias and 3 tuberculosis of the lung were positive for CEA, however the staining was weak and mainly found along the luminal border of the bronchiolar epithelial
lining cells.
In summary, the findings suggested that the immunohistochemical identification of CEA in tissue sections processed for routine histopathology was feasible. This might have diagnostic significance to the histopathologist and provide a solid basis for use of CEA in the follow-up management of patients with lung cancers.
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KEYWORD
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